Mechanisms of HTLV-1 persistence and transformation

Mechanisms of HTLV-1 persistence and transformation

Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL...

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Veröffentlicht in:British journal of cancer 2009-11, Vol.101 (9), p.1497-1501
Hauptverfasser: Boxus, M, Willems, L
Format: Artikel
Sprache:eng
Schlagworte:
Basic-Leucine Zipper Transcription Factors - physiology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell cycle
Cell growth
Cell Transformation, Viral
Chemotherapy
Cyclin-dependent kinases
DNA Damage
Drug Resistance
Epidemiology
Gene Products, rex - physiology
Gene Products, tax - physiology
Genomes
Genomic Instability
Human health sciences
Human T-lymphotropic virus
Human T-lymphotropic virus 1
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - physiology
Human T-lymphotropic virus 1/genetics/physiology
Humans
Kinases
Leukemia
Leukemia-Lymphoma, Adult T-Cell - pathology
Leukemia-Lymphoma, Adult T-Cell - virology
Leukemia-Lymphoma, Adult T-Cell/pathology/virology
Lymphoma
Medical research
mini-review
Minireview
Molecular Medicine
Oncologie
Oncology
Proteins
Retroviridae Proteins
Sciences de la santé humaine
Signal transduction
T-Lymphocytes - pathology
Tax increases
Transcription factors
Viral Proteins - physiology
Virus Replication
Viruses
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Zusammenfassung:Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/sj.bjc.6605345