The novel distribution of phosphodiesterase-4 subtypes within the rat retina

Abstract Phosphodiesterases (PDEs) are important regulators of signal transduction processes. While much is known about the function of cyclic GMP-specific PDEs in the retina, much less is known about the closely related, cyclic AMP-specific PDEs. The purpose of the present study is to characterize...

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Veröffentlicht in:	Neuroscience 2009-11, Vol.163 (4), p.1277-1291
Hauptverfasser:	Whitaker, C.M, Cooper, N.G.F
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Biological and medical sciences Blotting, Western cAMP Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Immunohistochemistry Isoenzymes - metabolism Male Neuroglia - metabolism Neurology Neurons - metabolism PDE4 PKA Rats Rats, Long-Evans Retina - enzymology Retina - metabolism retrograde Reverse Transcriptase Polymerase Chain Reaction rolipram Vertebrates: nervous system and sense organs
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