Disease Severity in a Murine Model of Lyme Borreliosis Is Associated with the Genotype of the Infecting Borrelia burgdorferi Sensu Stricto Strain

The pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing 2 distinct ribosomal DNA spacer restriction fragment–length polymorphism genotypes (RSTs) was assessed in a murine model of Lyme disease. B. burgdorferi was recovered from 71.5% and 26.6% of specimens from mice in...

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Veröffentlicht in:	The Journal of infectious diseases 2002-09, Vol.186 (6), p.782-791
Hauptverfasser:	Wang, Guiqing, Ojaimi, Caroline, Wu, Hongyan, Saksenberg, Victoria, Iyer, Radha, Liveris, Dionysios, McClain, Steve A., Wormser, Gary P., Schwartz, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankle - microbiology Ankle - pathology Antibodies, Bacterial - immunology Arthritis Arthritis, Infectious - microbiology Arthritis, Infectious - pathology Bacterial diseases Biological and medical sciences Blood Borrelia burgdorferi Borrelia burgdorferi - genetics Borrelia burgdorferi - immunology Borrelia burgdorferi - isolation & purification Borrelia burgdorferi - pathogenicity Disease Models, Animal DNA, Bacterial - genetics DNA, Ribosomal - genetics Experimental bacterial diseases and models Genotype Genotypes Infections Infectious diseases Lyme disease Lyme Disease - blood Lyme Disease - immunology Lyme Disease - microbiology Lyme Disease - pathology Major Article Medical sciences Mice Myocarditis - microbiology Myocarditis - pathology Phylogeny Polymerase chain reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Specimens Spirochaetales Time Factors Virulence - genetics
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Zusammenfassung:	The pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing 2 distinct ribosomal DNA spacer restriction fragment–length polymorphism genotypes (RSTs) was assessed in a murine model of Lyme disease. B. burgdorferi was recovered from 71.5% and 26.6% of specimens from mice infected with RST1 and RST3 isolates, respectively (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/343043