Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients
We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metallop...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2009-11, Vol.47 (11), p.3773-3776 |
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| container_title | Journal of Clinical Microbiology |
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| creator | Morris, Alison Alexander, Travis Radhi, Saba Lucht, Lorrie Sciurba, Frank C Kolls, Jay K Srivastava, Ruma Steele, Chad Norris, Karen A |
| description | We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease. |
| doi_str_mv | 10.1128/JCM.01712-09 |
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Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.01712-09</identifier><identifier>PMID: 19759224</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adult ; Aged ; Airway Obstruction - microbiology ; Airway Obstruction - pathology ; Biological and medical sciences ; Cohort Studies ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Infections - complications ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Matrix Metalloproteinase 12 - analysis ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Mycology ; Outpatients ; Pneumocystis ; Pneumocystis - isolation & purification ; Pneumocystis Infections - microbiology ; Pneumocystis Infections - pathology ; Sputum - chemistry ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of Clinical Microbiology, 2009-11, Vol.47 (11), p.3773-3776</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Society for Microbiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-dc1642eb71d410b7f6612f18c5eca564819c36b6ccfb0bf46eb871a59280892c3</citedby><cites>FETCH-LOGICAL-c495t-dc1642eb71d410b7f6612f18c5eca564819c36b6ccfb0bf46eb871a59280892c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772636/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772636/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3186,3187,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22115388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19759224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morris, Alison</creatorcontrib><creatorcontrib>Alexander, Travis</creatorcontrib><creatorcontrib>Radhi, Saba</creatorcontrib><creatorcontrib>Lucht, Lorrie</creatorcontrib><creatorcontrib>Sciurba, Frank C</creatorcontrib><creatorcontrib>Kolls, Jay K</creatorcontrib><creatorcontrib>Srivastava, Ruma</creatorcontrib><creatorcontrib>Steele, Chad</creatorcontrib><creatorcontrib>Norris, Karen A</creatorcontrib><title>Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Airway Obstruction - microbiology</subject><subject>Airway Obstruction - pathology</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Matrix Metalloproteinase 12 - analysis</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mycology</subject><subject>Outpatients</subject><subject>Pneumocystis</subject><subject>Pneumocystis - isolation & purification</subject><subject>Pneumocystis Infections - microbiology</subject><subject>Pneumocystis Infections - pathology</subject><subject>Sputum - chemistry</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Psychology</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Matrix Metalloproteinase 12 - analysis</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mycology</topic><topic>Outpatients</topic><topic>Pneumocystis</topic><topic>Pneumocystis - isolation & purification</topic><topic>Pneumocystis Infections - microbiology</topic><topic>Pneumocystis Infections - pathology</topic><topic>Sputum - chemistry</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, Alison</creatorcontrib><creatorcontrib>Alexander, Travis</creatorcontrib><creatorcontrib>Radhi, Saba</creatorcontrib><creatorcontrib>Lucht, Lorrie</creatorcontrib><creatorcontrib>Sciurba, Frank C</creatorcontrib><creatorcontrib>Kolls, Jay K</creatorcontrib><creatorcontrib>Srivastava, Ruma</creatorcontrib><creatorcontrib>Steele, Chad</creatorcontrib><creatorcontrib>Norris, Karen A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, Alison</au><au>Alexander, Travis</au><au>Radhi, Saba</au><au>Lucht, Lorrie</au><au>Sciurba, Frank C</au><au>Kolls, Jay K</au><au>Srivastava, Ruma</au><au>Steele, Chad</au><au>Norris, Karen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>47</volume><issue>11</issue><spage>3773</spage><epage>3776</epage><pages>3773-3776</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><coden>JCMIDW</coden><abstract>We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. 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| subjects | Adult Aged Airway Obstruction - microbiology Airway Obstruction - pathology Biological and medical sciences Cohort Studies Female Fundamental and applied biological sciences. Psychology HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Matrix Metalloproteinase 12 - analysis Medical sciences Microbiology Middle Aged Miscellaneous Mycology Outpatients Pneumocystis Pneumocystis - isolation & purification Pneumocystis Infections - microbiology Pneumocystis Infections - pathology Sputum - chemistry Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients |
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