Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients

We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metallop...

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Veröffentlicht in:	Journal of Clinical Microbiology 2009-11, Vol.47 (11), p.3773-3776
Hauptverfasser:	Morris, Alison, Alexander, Travis, Radhi, Saba, Lucht, Lorrie, Sciurba, Frank C, Kolls, Jay K, Srivastava, Ruma, Steele, Chad, Norris, Karen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Airway Obstruction - microbiology Airway Obstruction - pathology Biological and medical sciences Cohort Studies Female Fundamental and applied biological sciences. Psychology HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Matrix Metalloproteinase 12 - analysis Medical sciences Microbiology Middle Aged Miscellaneous Mycology Outpatients Pneumocystis Pneumocystis - isolation & purification Pneumocystis Infections - microbiology Pneumocystis Infections - pathology Sputum - chemistry Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.01712-09