C-Lysine Conjugates: pH-Controlled Light-Activated Reagents for Efficient Double-Stranded DNA Cleavage with Implications for Cancer Therapy

Double-stranded DNA cleavage of light-activated lysine conjugates is strongly enhanced at the slightly acidic pH (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2009-08, Vol.131 (32), p.11458-11470
Hauptverfasser:	Yang, Wang-Yong, Breiner, Boris, Kovalenko, Serguei V., Ben, Chi, Singh, Mani, LeGrand, Shauna N., Sang, Qing-Xiang Amy, Strouse, Geoffrey F., Copland, John A., Alabugin, Igor V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects DNA - metabolism DNA Cleavage - drug effects Humans Hydrogen-Ion Concentration Light Lysine - chemistry Lysine - pharmacology Models, Molecular Molecular Structure Neoplasms - drug therapy Photolysis - drug effects Plasmids - metabolism
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Beschreibung
Zusammenfassung:	Double-stranded DNA cleavage of light-activated lysine conjugates is strongly enhanced at the slightly acidic pH (
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja902140m