What Dose of External-Beam Radiation is High Enough for Prostate Cancer?

Purpose: To quantify the radiotherapy dose–response of prostate cancer, adjusted for prognostic factors in a mature cohort of men treated relatively uniformly at a single institution. Patients and Methods: The study cohort consisted of 1,530 men treated with three-dimensional conformal external-beam...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2007-07, Vol.68 (3), p.682-689
Hauptverfasser:	Eade, Thomas N., F.R.A.N.Z.C.R, Hanlon, Alexandra L., Ph.D, Horwitz, Eric M., M.D, Buyyounouski, Mark K., M.D, Hanks, Gerald E., M.D, Pollack, Alan, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged BEAMS CARCINOMAS Cohort Studies Dose Dose-Response Relationship, Radiation FAILURES Hematology, Oncology and Palliative Medicine Humans Incidence Lymphatic Metastasis Male METASTASES MULTIVARIATE ANALYSIS Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - prevention & control PATIENTS Pennsylvania - epidemiology PROSTATE Prostate cancer Prostatic Neoplasms - epidemiology Prostatic Neoplasms - radiotherapy Radiation Dosage RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Conformal - statistics & numerical data RESPONSE FUNCTIONS Risk Assessment - methods Risk Factors Treatment Outcome
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Beschreibung
Zusammenfassung:	Purpose: To quantify the radiotherapy dose–response of prostate cancer, adjusted for prognostic factors in a mature cohort of men treated relatively uniformly at a single institution. Patients and Methods: The study cohort consisted of 1,530 men treated with three-dimensional conformal external-beam radiotherapy between 1989 and 2002. Patients were divided into four isocenter dose groups:
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2007.01.008