P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells

P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells

Alternatively, using conditional ablation of LC in Langerin-DTR mice and the contact sensitizer DNFB (which modifies self proteins), we showed that epithelial LC are dispensable for priming CD8+ CTL mediating delayed-type hypersensitivity responses. [...] using a structurally related but tolerogenic...

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Veröffentlicht in:Retrovirology 2009-10, Vol.6 (Suppl 3), p.P150-P150, Article P150
Hauptverfasser: Dubois, B, de Aguero, M Gomez, Le Borgne, M, Gouanvic, M, Vocanson, M, Kaiserlian, D
Format: Artikel
Sprache:eng
Schlagworte:
Cytotoxicity
Human health and pathology
Immunology
Infectious diseases
Life Sciences
Poster Presentation
Vaccines
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Zusammenfassung:Alternatively, using conditional ablation of LC in Langerin-DTR mice and the contact sensitizer DNFB (which modifies self proteins), we showed that epithelial LC are dispensable for priming CD8+ CTL mediating delayed-type hypersensitivity responses. [...] using a structurally related but tolerogenic hapten, DNTB, we demonstrated that LC migrate to draining lymph nodes for Ag presentation to CD8+ T cells, but were unable to prime CTL.
ISSN:1742-4690
1742-4690
DOI:10.1186/1742-4690-6-S3-P150