Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population

Objective We sought to determine whether polymorphisms in the transforming growth factor (TGF)-β3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads. Study Design Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-β3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-β3 gene. Results Only 1 of the TGF-β3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratiomulti-locus adj , 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-β3 variants had no effect on risk of PIH. Conclusion A fetal TGF-β3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.