Okundoperoxide, a Bicyclic Cyclofarnesylsesquiterpene Endoperoxide from Scleria striatinux with Antiplasmodial Activity

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-02, Vol.72 (2), p.280-283
Hauptverfasser:	Efange, Simon M. N, Brun, Reto, Wittlin, Sergio, Connolly, Joseph D, Hoye, Thomas R, McAkam, Thomas, Makolo, Felix L, Mbah, James A, Nelson, Dorian P, Nyongbela, Kennedy D, Wirmum, Clare K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology antiprotozoal activity Biological and medical sciences chemical control chemical structure Chloroquine - pharmacology Cyperaceae Cyperaceae - chemistry disease control Drug Resistance - drug effects General pharmacology human diseases malaria Medical sciences medicinal properties Molecular Structure Nuclear Magnetic Resonance, Biomolecular okundoperoxide peroxides Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects Scleria Scleria striatinux Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology sesquiterpenoids spectral analysis stereochemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np800338p