Synthesis of biotinylated OSW-1

OSW-1 is a highly potent anticancer natural saponin with unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps. OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s)...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-09, Vol.19 (17), p.5166-5168
Hauptverfasser:	Kang, Ying, Lou, Changgang, Ahmed, Kausar Begam Riaz, Huang, Peng, Jin, Zhendong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - toxicity Biological and medical sciences Biotin - analogs & derivatives Biotin - chemical synthesis Biotin - chemistry Biotin - toxicity Biotinylated Biotinylation Cell Line, Tumor Cholestenones - chemical synthesis Cholestenones - chemistry Cholestenones - toxicity General aspects Humans Medical sciences Natural product OSW-1 Pharmacology. Drug treatments Saponin Saponins - chemical synthesis Saponins - chemistry Saponins - toxicity Synthesis
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Beschreibung
Zusammenfassung:	OSW-1 is a highly potent anticancer natural saponin with unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps. OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.07.062