Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio R...

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Veröffentlicht in:	Nature genetics 2009-08, Vol.41 (8), p.879-881
Hauptverfasser:	Boerwinkle, Eric, Wolf, Philip A, Sotoodehnia, Nona, Rice, Kenneth M, Harris, Tamara B, Aspelund, Thor, Köttgen, Anna, Meitinger, Thomas, Soliman, Elsayed Z, Schnabel, Renate B, Wang, Thomas J, Gudnason, Vilmundur, Rivadeneira, Fernando, van Duijn, Cornelia M, Bis, Joshua C, Larson, Martin G, van Noord, Charlotte, Pfeufer, Arne, Eiríksdottir, Gudny, Dehghan, Abbas, Lumley, Thomas, Vasan, Ramachandran S, Alonso, Alvaro, Heeringa, Jan, Hofman, Albert, Lunetta, Kathryn L, Levy, Daniel, Witteman, Jacqueline C M, Smith, Albert V, Uitterlinden, André G, Chamberlain, Alanna M, Agarwal, Sunil K, Heckbert, Susan R, Perz, Siegfried, Wang, Ke, Lubitz, Steven A, Kao, W H Linda, Smith, Nicholas L, Ellinor, Patrick T, Steinbeck, Gerhard, Marciante, Kristin D, Li, Man, Mueller, Martina, Wichmann, H-Erich, D'Agostino Sr, Ralph B, Chakravarti, Aravinda, Newton-Cheh, Christopher, Launer, Lenore J, Kääb, Stefan, Benjamin, Emelia J, Stricker, Bruno H Ch, Sinner, Moritz F, Psaty, Bruce M, Arking, Dan E, Rotter, Jerome I, Ehret, Georg B
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Atrial fibrillation Atrial Fibrillation - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cardiac arrhythmia Cardiac dysrhythmias Cardiology. Vascular system Chromosomes, Human, Pair 16 - genetics Community Data collection Disease European Continental Ancestry Group - genetics Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Heart Heart failure Homeodomain Proteins - genetics Human Genetics Humans Industrialized nations Inflation Medical sciences Meta-analysis Meta-Analysis as Topic Mutation - genetics Polymorphism, Single Nucleotide - genetics Reproducibility of Results Risk factors Studies
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Zusammenfassung:	We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10−7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10−11; combined RR = 1.25; combined P = 1.8 × 10−15).
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.416