One-Pot, Direct Incorporation of [¹¹C]CO₂ into Carbamates

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of ¹¹CO₂ with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of ¹¹C-labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strat...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (19), p.3482-3485
Hauptverfasser:	Hooker, Jacob M, Reibel, Achim T, Hill, Sidney M, Schueller, Michael J, Fowler, Joanna S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic - chemistry carbamates Carbamates - chemistry Carbon Dioxide - chemistry Carbon Radioisotopes - chemistry carbon‐11 isotopic labeling Positron-Emission Tomography radiochemistry Radiopharmaceuticals - chemical synthesis
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Beschreibung
Zusammenfassung:	Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of ¹¹CO₂ with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of ¹¹C-labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200900112