Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

Understanding as much as possible about proteins in the shortest amount of time has long been a goal of hydrogen exchange (HX) MS. Recent technological advances have led to improvements in the technique, but has this goal yet been achieved? (To listen to a podcast about this Feature, please go to th...

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Veröffentlicht in:	Analytical chemistry (Washington) 2009-10, Vol.81 (19), p.7870-7875
1. Verfasser:	Engen, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Analytical, structural and metabolic biochemistry Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Biological and medical sciences Chemistry Deuterium - chemistry Deuterium Exchange Measurement - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology Hydrogen - chemistry Isotope Labeling Mass Spectrometry Protein Conformation Proteins Recombinant Proteins - chemistry Spectrometric and optical methods
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Beschreibung
Zusammenfassung:	Understanding as much as possible about proteins in the shortest amount of time has long been a goal of hydrogen exchange (HX) MS. Recent technological advances have led to improvements in the technique, but has this goal yet been achieved? (To listen to a podcast about this Feature, please go to the Analytical Chemistry Web site at pubs.acs.org/journal/ancham.).
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac901154s