Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astroc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biological physics 2009-10, Vol.35 (4), p.425-445
Hauptverfasser:	Postnov, D. E, Koreshkov, R. N, Brazhe, N. A, Brazhe, A. R, Sosnovtseva, O. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocyte Biochemistry Biological and Medical Physics Biophysics Calcium waves Cellular biology Complex Fluids and Microfluidics Complex Systems Mathematical models Neurology Neuron Neurosciences Original Paper Physics Physics and Astronomy Signal transduction Soft and Granular Matter Tripartite synapse
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.
ISSN:	0092-0606 1573-0689
DOI:	10.1007/s10867-009-9156-x