Epithelial cells as immune effector cells: The role of CD40

Abstract Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results...

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Veröffentlicht in:Seminars in immunology 2009-10, Vol.21 (5), p.289-292
Hauptverfasser: Dugger, Kari, Lowder, Thomas W, Tucker, Torry A, Schwiebert, Lisa M
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Sprache:eng
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Zusammenfassung:Abstract Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2009.06.002