Signaling by gasotransmitters

Signaling by gasotransmitters

Nitric oxide is well established as a major signaling molecule. Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems. This Review focuses on mechanisms whereby they signal by binding to metal centers in m...

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Veröffentlicht in:Science signaling 2009-04, Vol.2 (68), p.re2-re2
Hauptverfasser: Mustafa, Asif K, Gadalla, Moataz M, Snyder, Solomon H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbon Monoxide - metabolism
Humans
Hydrogen Sulfide - metabolism
Models, Biological
Muscle, Smooth, Vascular - metabolism
Muscle, Smooth, Vascular - physiology
Nitric Oxide - metabolism
Signal Transduction - physiology
Vasodilation - physiology
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Beschreibung
Zusammenfassung:Nitric oxide is well established as a major signaling molecule. Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems. This Review focuses on mechanisms whereby they signal by binding to metal centers in metalloproteins, such as in guanylyl cyclase, or modifying sulfhydryl groups in protein targets.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.268re2