Oxidative stress, thermogenesis and evolution of uncoupling proteins

Oxidative stress, thermogenesis and evolution of uncoupling proteins

The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying se...

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Veröffentlicht in:Journal of biology (London, England) England), 2009, Vol.8 (6), p.58-58
Hauptverfasser: Rial, Eduardo, Zardoya, Rafael
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Evolution, Molecular
Ion Channels - genetics
Minireview
Mitochondrial Proteins - genetics
Multigene Family
Oxidative Stress
Phylogeny
Thermogenesis
Uncoupling Protein 1
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Zusammenfassung:The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.
ISSN:1475-4924
1478-5854
1475-4924
DOI:10.1186/jbiol155