Structural basis for exon recognition by a group II intron

Structural basis for exon recognition by a group II intron

Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-Å crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron struc...

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Veröffentlicht in:Nature structural & molecular biology 2008-11, Vol.15 (11), p.1221-1222
Hauptverfasser: Toor, Navtej, Rajashankar, Kanagalaghatta, Keating, Kevin S, Pyle, Anna Marie
Format: Artikel
Sprache:eng
Schlagworte:
Binding sites
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
brief-communication
CRYSTAL STRUCTURE
Crystallography, X-Ray
Deoxyribonucleic acid
DNA
EXONS
Health aspects
INTRONS
Life Sciences
MATERIALS SCIENCE
Membrane Biology
Models, Molecular
Molecular biology
Molecular Sequence Data
MOLECULES
Nucleic Acid Conformation
OLIGONUCLEOTIDES
Physiological aspects
Protein Structure
Ribonucleic acid
RNA
RNA splicing
SPLICING
Structure
SUBSTRATES
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Beschreibung
Zusammenfassung:Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-Å crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb.1509