Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR=fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a coppe...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (27), p.4973-4976
Hauptverfasser: Godula, Kamil, Rabuka, David, Nam, Ki Tae, Bertozzi, Carolyn R
Format: Artikel
Sprache:eng
Schlagworte:
click chemistry
Fluorescent Dyes - chemistry
glycopolymers
Glycoproteins - chemistry
Lectins - chemistry
Microarray Analysis
micropatterning
mucin
Mucins - chemistry
polymerization
Polysaccharides - chemical synthesis
Polysaccharides - chemistry
Surface Properties
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Beschreibung
Zusammenfassung:Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR=fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a copper catalyst. The surface-bound glycopolymers bind lectins in a ligand-specific manner.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200805756