Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors

Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors

Human embryonic stem cells (hESCs) are self‐renewing pluripotent cells that have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types, including cells with n...

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Veröffentlicht in:Stem cells (Dayton, Ohio) Ohio), 2009-01, Vol.27 (1), p.78-87
Hauptverfasser: Erceg, Slaven, Ronaghi, Mohammad, Stojković, Miodrag
Format: Artikel
Sprache:eng
Schlagworte:
Cell culture
Cell Differentiation
Cellular therapy
Embryonic Stem Cells - cytology
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Human embryonic stem cells
Humans
Neural differentiation
Neurons - cytology
Oligodendroglia - cytology
Organ Specificity
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Zusammenfassung:Human embryonic stem cells (hESCs) are self‐renewing pluripotent cells that have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types, including cells with neural characteristics. Therefore, this review summarizes early neural development and the potential of hESCs to differentiate under in vitro conditions, examining at the same time the potential use of differentiated hESCs for therapeutic applications for neural tissue and cell regeneration. STEM CELLS 2009;27:78–87
ISSN:1066-5099
1549-4918
DOI:10.1634/stemcells.2008-0543