Urinary 17-KS and 17-OHCS as Markers of Endocrine Disruption by Air Pollution in Primary School Children

The present study was undertaken to determine the effects of air pollution on urinary excretion of 17-ketosteroids (17-KS) and 17-hydroxycorticosteroids (17-OHCS), which are markers of adrenal cortex functions, in primary school children from five schools with different levels of air pollution. One...

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Veröffentlicht in:	Environmental Health and Preventive Medicine 2000, Vol.4 (4), p.221-223
1. Verfasser:	WATANABE, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Air. Soil. Water. Waste. Feeding Biological and medical sciences Endocrine disruptors Endocrine system Endocrinopathies Environment. Living conditions Environmental health Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Public health. Hygiene Public health. Hygiene-occupational medicine Short Communication
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Zusammenfassung:	The present study was undertaken to determine the effects of air pollution on urinary excretion of 17-ketosteroids (17-KS) and 17-hydroxycorticosteroids (17-OHCS), which are markers of adrenal cortex functions, in primary school children from five schools with different levels of air pollution. One hundred and twentynine fourth-grade children were included in the study. Urinary excretion of 17-KS and 17-OHCS were significantly lower in male children living in polluted areas than in children living in clean areas. We conclude that adrenal cortex functions before puberty can serve as practical markers of endocrine disruption by environmental factors in epidemiological studies.
ISSN:	1342-078X 1347-4715
DOI:	10.1007/BF02931262