Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer
Background: Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to discover biomarkers for gastric cancer. Methods: Surface-enhanced laser desorpti...
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| Veröffentlicht in: | British journal of cancer 2009-07, Vol.101 (2), p.295-302 |
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| creator | Mohri, Y Mohri, T Wei, W Qi, Y-J Martin, A Miki, C Kusunoki, M Ward, D G Johnson, P J |
| description | Background:
Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to discover biomarkers for gastric cancer.
Methods:
Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases. Expression differences were confirmed by enzyme-linked immunosorbent assay.
Results:
Tissue analysis shows human neutrophil peptides 1–3 (HNPs 1–3) elevated 10-fold (
P
=0.001) in gastric cancer relative to adjacent normal mucosa. Macrophage migration inhibitory factor (MIF) was increased five-fold (
P
=1.84 × 10
−7
) in the serum of gastric cancer patients relative to individuals with benign gastric disease. The large increase in MIF concentration in serum gives an area under the receiver operating characteristic curve of 0.85.
Conclusions:
Proteomic analyses of serum and tissue indicate that HNPs 1–3 and MIF have potential as biomarkers for gastric cancer. In particular MIF may be useful, either alone or in combination with other markers, for diagnosing and monitoring gastric cancer. |
| doi_str_mv | 10.1038/sj.bjc.6605138 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2720195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67485398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-365f2d5fc5967c268f82336b8529375d1dc1bbce4dd29902a7e544c4cd50d2a93</originalsourceid><addsrcrecordid>eNqFkk2L1TAUhoMoznV061KCoLveyUfTJhtBBj8GBtzoOqT56M21TWrSCrNz5w_wH_pLTLllRgVxFZLznPO-OecA8BSjPUaUX-TjvjvqfdMghim_B3aYUVJhTtr7YIcQaiskCDoDj3I-lqtAvH0IzrBgDNWE7MD3K2PD7J3XavYxwOjgqHSK00H1Fo6-T6d3Hw6-83NMN9ApXU6ogoGHZVQBBrvMa4Yf4GSn2RubIf757QeFKsMpzquAGmDn46jSZ5sydCW_V3lOXkOtgrbpMXjg1JDtk-08B5_evvl4-b66_vDu6vL1daUZbuaKNswRw5xmomk1abjjhNKm44wI2jKDjcZdp21tDBECEdVaVte61oYhQ5Sg5-DVqe60dKM1unhLapBT8sXbjYzKyz8jwR9kH79K0hJU2lYKvNwKpPhlsXmWo8_aDoMKNi5ZNm3NGRX8vyBBBDUY4wI-_ws8xiWF0gVJaJkZ5e0quz9BZTY5J-tuLWMk102Q-SjLJshtE0rCs98_eodvoy_Aiw1QWavBpTIHn285ggXlBK_KFycul1Dobbqz9w_pX_Cs0HM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230003875</pqid></control><display><type>article</type><title>Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer</title><source>MEDLINE</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Mohri, Y ; Mohri, T ; Wei, W ; Qi, Y-J ; Martin, A ; Miki, C ; Kusunoki, M ; Ward, D G ; Johnson, P J</creator><creatorcontrib>Mohri, Y ; Mohri, T ; Wei, W ; Qi, Y-J ; Martin, A ; Miki, C ; Kusunoki, M ; Ward, D G ; Johnson, P J</creatorcontrib><description>Background:
Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to discover biomarkers for gastric cancer.
Methods:
Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases. Expression differences were confirmed by enzyme-linked immunosorbent assay.
Results:
Tissue analysis shows human neutrophil peptides 1–3 (HNPs 1–3) elevated 10-fold (
P
=0.001) in gastric cancer relative to adjacent normal mucosa. Macrophage migration inhibitory factor (MIF) was increased five-fold (
P
=1.84 × 10
−7
) in the serum of gastric cancer patients relative to individuals with benign gastric disease. The large increase in MIF concentration in serum gives an area under the receiver operating characteristic curve of 0.85.
Conclusions:
Proteomic analyses of serum and tissue indicate that HNPs 1–3 and MIF have potential as biomarkers for gastric cancer. In particular MIF may be useful, either alone or in combination with other markers, for diagnosing and monitoring gastric cancer.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6605138</identifier><identifier>PMID: 19550422</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Aged, 80 and over ; alpha-Defensins - biosynthesis ; alpha-Defensins - blood ; Antibodies ; Biological and medical sciences ; Biomarkers ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - blood ; Biomedical and Life Sciences ; Biomedicine ; Blood Proteins - analysis ; Cancer Research ; Drug Resistance ; Endoscopy ; Enzyme-Linked Immunosorbent Assay ; Enzymes ; Epidemiology ; Female ; Gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; Hospitals ; Humans ; Macrophage Migration-Inhibitory Factors - biosynthesis ; Macrophage Migration-Inhibitory Factors - blood ; Male ; Mass spectrometry ; Medical research ; Medical sciences ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Proteins - blood ; Neoplasm Staging ; Neutrophils ; Oncology ; Peptides ; Protein Array Analysis ; Proteins ; Proteomics - methods ; Scientific imaging ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; Stomach Neoplasms - blood ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Tumors</subject><ispartof>British journal of cancer, 2009-07, Vol.101 (2), p.295-302</ispartof><rights>The Author(s) 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 21, 2009</rights><rights>Copyright © 2009 Cancer Research UK 2009 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-365f2d5fc5967c268f82336b8529375d1dc1bbce4dd29902a7e544c4cd50d2a93</citedby><cites>FETCH-LOGICAL-c516t-365f2d5fc5967c268f82336b8529375d1dc1bbce4dd29902a7e544c4cd50d2a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720195/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720195/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21938215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19550422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohri, Y</creatorcontrib><creatorcontrib>Mohri, T</creatorcontrib><creatorcontrib>Wei, W</creatorcontrib><creatorcontrib>Qi, Y-J</creatorcontrib><creatorcontrib>Martin, A</creatorcontrib><creatorcontrib>Miki, C</creatorcontrib><creatorcontrib>Kusunoki, M</creatorcontrib><creatorcontrib>Ward, D G</creatorcontrib><creatorcontrib>Johnson, P J</creatorcontrib><title>Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to discover biomarkers for gastric cancer.
Methods:
Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases. Expression differences were confirmed by enzyme-linked immunosorbent assay.
Results:
Tissue analysis shows human neutrophil peptides 1–3 (HNPs 1–3) elevated 10-fold (
P
=0.001) in gastric cancer relative to adjacent normal mucosa. Macrophage migration inhibitory factor (MIF) was increased five-fold (
P
=1.84 × 10
−7
) in the serum of gastric cancer patients relative to individuals with benign gastric disease. The large increase in MIF concentration in serum gives an area under the receiver operating characteristic curve of 0.85.
Conclusions:
Proteomic analyses of serum and tissue indicate that HNPs 1–3 and MIF have potential as biomarkers for gastric cancer. In particular MIF may be useful, either alone or in combination with other markers, for diagnosing and monitoring gastric cancer.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alpha-Defensins - biosynthesis</subject><subject>alpha-Defensins - blood</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Proteins - analysis</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Endoscopy</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Macrophage Migration-Inhibitory Factors - biosynthesis</subject><subject>Macrophage Migration-Inhibitory Factors - blood</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Proteins - blood</subject><subject>Neoplasm Staging</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>Peptides</subject><subject>Protein Array Analysis</subject><subject>Proteins</subject><subject>Proteomics - methods</subject><subject>Scientific imaging</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk2L1TAUhoMoznV061KCoLveyUfTJhtBBj8GBtzoOqT56M21TWrSCrNz5w_wH_pLTLllRgVxFZLznPO-OecA8BSjPUaUX-TjvjvqfdMghim_B3aYUVJhTtr7YIcQaiskCDoDj3I-lqtAvH0IzrBgDNWE7MD3K2PD7J3XavYxwOjgqHSK00H1Fo6-T6d3Hw6-83NMN9ApXU6ogoGHZVQBBrvMa4Yf4GSn2RubIf757QeFKsMpzquAGmDn46jSZ5sydCW_V3lOXkOtgrbpMXjg1JDtk-08B5_evvl4-b66_vDu6vL1daUZbuaKNswRw5xmomk1abjjhNKm44wI2jKDjcZdp21tDBECEdVaVte61oYhQ5Sg5-DVqe60dKM1unhLapBT8sXbjYzKyz8jwR9kH79K0hJU2lYKvNwKpPhlsXmWo8_aDoMKNi5ZNm3NGRX8vyBBBDUY4wI-_ws8xiWF0gVJaJkZ5e0quz9BZTY5J-tuLWMk102Q-SjLJshtE0rCs98_eodvoy_Aiw1QWavBpTIHn285ggXlBK_KFycul1Dobbqz9w_pX_Cs0HM</recordid><startdate>20090721</startdate><enddate>20090721</enddate><creator>Mohri, Y</creator><creator>Mohri, T</creator><creator>Wei, W</creator><creator>Qi, Y-J</creator><creator>Martin, A</creator><creator>Miki, C</creator><creator>Kusunoki, M</creator><creator>Ward, D G</creator><creator>Johnson, P J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090721</creationdate><title>Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer</title><author>Mohri, Y ; Mohri, T ; Wei, W ; Qi, Y-J ; Martin, A ; Miki, C ; Kusunoki, M ; Ward, D G ; Johnson, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-365f2d5fc5967c268f82336b8529375d1dc1bbce4dd29902a7e544c4cd50d2a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alpha-Defensins - biosynthesis</topic><topic>alpha-Defensins - blood</topic><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Proteins - analysis</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Endoscopy</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Macrophage Migration-Inhibitory Factors - biosynthesis</topic><topic>Macrophage Migration-Inhibitory Factors - blood</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Proteins - blood</topic><topic>Neoplasm Staging</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>Peptides</topic><topic>Protein Array Analysis</topic><topic>Proteins</topic><topic>Proteomics - methods</topic><topic>Scientific imaging</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohri, Y</creatorcontrib><creatorcontrib>Mohri, T</creatorcontrib><creatorcontrib>Wei, W</creatorcontrib><creatorcontrib>Qi, Y-J</creatorcontrib><creatorcontrib>Martin, A</creatorcontrib><creatorcontrib>Miki, C</creatorcontrib><creatorcontrib>Kusunoki, M</creatorcontrib><creatorcontrib>Ward, D G</creatorcontrib><creatorcontrib>Johnson, P J</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohri, Y</au><au>Mohri, T</au><au>Wei, W</au><au>Qi, Y-J</au><au>Martin, A</au><au>Miki, C</au><au>Kusunoki, M</au><au>Ward, D G</au><au>Johnson, P J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2009-07-21</date><risdate>2009</risdate><volume>101</volume><issue>2</issue><spage>295</spage><epage>302</epage><pages>295-302</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to discover biomarkers for gastric cancer.
Methods:
Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases. Expression differences were confirmed by enzyme-linked immunosorbent assay.
Results:
Tissue analysis shows human neutrophil peptides 1–3 (HNPs 1–3) elevated 10-fold (
P
=0.001) in gastric cancer relative to adjacent normal mucosa. Macrophage migration inhibitory factor (MIF) was increased five-fold (
P
=1.84 × 10
−7
) in the serum of gastric cancer patients relative to individuals with benign gastric disease. The large increase in MIF concentration in serum gives an area under the receiver operating characteristic curve of 0.85.
Conclusions:
Proteomic analyses of serum and tissue indicate that HNPs 1–3 and MIF have potential as biomarkers for gastric cancer. In particular MIF may be useful, either alone or in combination with other markers, for diagnosing and monitoring gastric cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19550422</pmid><doi>10.1038/sj.bjc.6605138</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over alpha-Defensins - biosynthesis alpha-Defensins - blood Antibodies Biological and medical sciences Biomarkers Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Blood Proteins - analysis Cancer Research Drug Resistance Endoscopy Enzyme-Linked Immunosorbent Assay Enzymes Epidemiology Female Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Hospitals Humans Macrophage Migration-Inhibitory Factors - biosynthesis Macrophage Migration-Inhibitory Factors - blood Male Mass spectrometry Medical research Medical sciences Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Proteins - blood Neoplasm Staging Neutrophils Oncology Peptides Protein Array Analysis Proteins Proteomics - methods Scientific imaging Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Stomach Neoplasms - blood Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Tumors |
| title | Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer |
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