Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

Objective There is limited pharmacokinetic data available for the combination artesunate + amodiaquine, which is used widely to treat uncomplicated malaria. This study examines the bioavailability and tolerability of a fixed (200 mg artesunate + 540 mg amodiaquine) and loose (200 mg + 612 mg) combin...

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Veröffentlicht in:	European journal of clinical pharmacology 2009-08, Vol.65 (8), p.809-821
Hauptverfasser:	Navaratnam, Visweswaran, Ramanathan, Surash, Wahab, Mohd Suhaimi Ab, Siew Hua, Gan, Mansor, Sharif Mahsufi, Kiechel, Jean-René, Vaillant, Michel, Taylor, Walter R. J, Olliaro, Piero
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amodiaquine - adverse effects Amodiaquine - blood Amodiaquine - pharmacokinetics Analysis of Variance Antimalarials - administration & dosage Antimalarials - blood Antimalarials - pharmacokinetics Area Under Curve Artemisinins - administration & dosage Artemisinins - blood Artemisinins - pharmacokinetics Asian Continental Ancestry Group - statistics & numerical data Biological and medical sciences Biological Availability Biomarkers - blood Biomedical and Life Sciences Biomedicine Chi-Square Distribution Cross-Over Studies Drug Combinations Drug therapy Drug Therapy, Combination Female Humans Malaria Malaysia Male Medical sciences Pharmacokinetics and Disposition Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Reference Values Time Factors
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