Claudin-2-dependent Changes in Noncharged Solute Flux Are Mediated by the Extracellular Domains and Require Attachment to the PDZ-scaffold

Claudin-2-dependent Changes in Noncharged Solute Flux Are Mediated by the Extracellular Domains and Require Attachment to the PDZ-scaffold

Paracellular transport through the tight junction shows selectivity for both ionic charge and solute size. It is known that charged residues on the extracellular loops of claudins control charge selectivity. It is also known that inducible expression of claudin‐2, but not claudin‐4, will selectively...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2009-05, Vol.1165 (1), p.82-87
Hauptverfasser: Van Itallie, Christina M., Holmes, Jennifer, Bridges, Arlene, Anderson, James Melvin
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Membrane Permeability
Cells, Cultured
claudin
Claudin-4
Dogs
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Models, Biological
paracellular
PDZ
PDZ Domains
permeability
tight junction
Tight Junctions - metabolism
Transfection
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Zusammenfassung:Paracellular transport through the tight junction shows selectivity for both ionic charge and solute size. It is known that charged residues on the extracellular loops of claudins control charge selectivity. It is also known that inducible expression of claudin‐2, but not claudin‐4, will selectively increase the permeability for polyethylene glycol (PEG) molecules which are
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2009.04052.x