Prognosis and predictive value of KIT exon 11 deletion in GISTs

Background: KIT exon 11 mutations are observed in 60% of gastrointestinal stromal tumours (GIST). Exon 11 codes for residues Tyr568 and Tyr570, which play a major role in signal transduction and degradation of KIT. Our aim was to compare the outcome of patients with deletion of both Tyr568–570 (delT...

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Veröffentlicht in:	British journal of cancer 2009-07, Vol.101 (1), p.7-11
Hauptverfasser:	Bachet, J-B, Hostein, I, Le Cesne, A, Brahimi, S, Beauchet, A, Tabone-Eglinger, S, Subra, F, Bui, B, Duffaud, F, Terrier, P, Coindre, J-M, Blay, J-Y, Emile, J-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Benzamides Biomedical and Life Sciences Biomedicine Cancer Research Clinical Study Disease-Free Survival Drug Resistance Epidemiology Exons Female Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Gene Deletion Humans Imatinib Mesylate Life Sciences Male Medical prognosis Medical research Metastasis Middle Aged Molecular Medicine Mutation Oncology Piperazines - therapeutic use Proto-Oncogene Proteins c-kit - genetics Pyrimidines - therapeutic use Retrospective Studies Signal transduction Small intestine Survival Rate Tumors Young Adult
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Zusammenfassung:	Background: KIT exon 11 mutations are observed in 60% of gastrointestinal stromal tumours (GIST). Exon 11 codes for residues Tyr568 and Tyr570, which play a major role in signal transduction and degradation of KIT. Our aim was to compare the outcome of patients with deletion of both Tyr568–570 (delTyr) and the most frequent deletion delWK557–558 (delWK). Methods: Pathology and clinical characteristics of 68 patients with delTyr ( n =26) or delWK ( n =42) were reviewed and compared. Results: GISTs with delTyr were more frequently extragastric than those with delWK (69 vs 26%, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6605117