Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging

Hyaluronic‐acid immobilized monodisperse magnetic nanocrystals (HA‐DN/MNCs) are synthesized. Dopamine, the analogue of 3,4‐dihydroxy‐L‐phenylalanine responsible for the adhesion properties in proteins excreted by mussels, plays a key role in the surface modification of nanocrystals. HA‐DN/MNCs exhib...

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Veröffentlicht in:	Advanced materials (Weinheim) 2008-11, Vol.20 (21), p.4154-4157
Hauptverfasser:	Lee, Yuhan, Lee, Haeshin, Kim, Young Beom, Kim, Jaeyoon, Hyeon, Taeghwan, Park, HyunWook, Messersmith, Phillip B., Park, Tae Gwan
Format:	Artikel
Sprache:	eng
Schlagworte:	biomedical materials magnetic nanoparticles magnetic resonance targeted cancer imaging
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Zusammenfassung:	Hyaluronic‐acid immobilized monodisperse magnetic nanocrystals (HA‐DN/MNCs) are synthesized. Dopamine, the analogue of 3,4‐dihydroxy‐L‐phenylalanine responsible for the adhesion properties in proteins excreted by mussels, plays a key role in the surface modification of nanocrystals. HA‐DN/MNCs exhibit great stability in aqueous solution, applicable for in vivo targeted‐cancer imaging.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.200800756