Clinical predictors of early second event in patients with clinically isolated syndrome

This study aimed to determine the predictors of increased risk of a second demyelinating event within the first year of an initial demyelinating event (IDE) suggestive of early multiple sclerosis (MS). Patients with MS or clinically isolated syndrome (CIS) seen at the UCSF MS Center within one year...

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Veröffentlicht in:	Journal of neurology 2009-07, Vol.256 (7), p.1061-1066
Hauptverfasser:	Mowry, Ellen M., Pesic, Mila, Grimes, Barbara, Deen, Serina R., Bacchetti, Peter, Waubant, Emmanuelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution Age Factors Biological and medical sciences Central Nervous System - immunology Central Nervous System - pathology Central Nervous System - physiopathology Continental Population Groups Disease Epidemiology Ethnicity Female Humans Immunologic Factors - therapeutic use Magnetic resonance imaging Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuroradiology Neurosciences Original Communication Patients Prognosis Proportional Hazards Models Recurrence Risk Factors Severity of Illness Index Steroids - therapeutic use Young Adult
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Zusammenfassung:	This study aimed to determine the predictors of increased risk of a second demyelinating event within the first year of an initial demyelinating event (IDE) suggestive of early multiple sclerosis (MS). Patients with MS or clinically isolated syndrome (CIS) seen at the UCSF MS Center within one year of the IDE were studied. Univariate and multivariate Cox models were used to analyze predictors of having a second event within 1 year of the IDE. Of 330 patients with MS/CIS, 111 had a second event within 1 year. Non-white race/ethnicity (HR = 2.39, 95% CI [1.58, 3.60], p
ISSN:	0340-5354 1432-1459
DOI:	10.1007/s00415-009-5063-0