Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity

In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Exercise and sport sciences reviews 2008-10, Vol.36 (4), p.187-192
Hauptverfasser:	Good, Deborah J, Coyle, Christopher A, Fox, Dana L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Gene Deletion Genetic Linkage Humans Mice Mice, Knockout Motivation Motor Activity - genetics Obesity - genetics Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
ISSN:	0091-6331 1538-3008
DOI:	10.1097/JES.0b013e31818782dd