Antimalarial Bromophycolides J−Q from the Fijian Red Alga Callophycus serratus

Antimalarial Bromophycolides J−Q from the Fijian Red Alga Callophycus serratus

Bromophycolides J−Q (1−8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene−benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides...

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Veröffentlicht in:Journal of organic chemistry 2009-04, Vol.74 (7), p.2736-2742
Hauptverfasser: Lane, Amy L, Stout, E. Paige, Lin, An-Shen, Prudhomme, Jacques, Le Roch, Karine, Fairchild, Craig R, Franzblau, Scott G, Hay, Mark E, Aalbersberg, William, Kubanek, Julia
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Animals
Antimalarials - chemistry
Antimalarials - pharmacology
Chemistry
Diterpenes - chemistry
Diterpenes - pharmacology
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Magnetic Resonance Spectroscopy
Molecular Structure
Organic chemistry
Plasmodium falciparum - drug effects
Preparations and properties
Rhodophyta - chemistry
Structure-Activity Relationship
Terpenoids
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Zusammenfassung:Bromophycolides J−Q (1−8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene−benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9−18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo900008w