Metathesis cascade strategies (ROM–RCM–CM): a DOS approach to skeletally diverse sultams

The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM–RCM–CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels–Alder (IMDA) reactio...

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Veröffentlicht in:	Tetrahedron 2009-06, Vol.65 (26), p.4992-5000
Hauptverfasser:	Jeon, Kyu Ok, Rayabarapu, Dinesh, Rolfe, Alan, Volp, Kelly, Omar, Iman, Hanson, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cascade Chemistry DOS Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties RCM Sultam
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Zusammenfassung:	The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM–RCM–CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels–Alder (IMDA) reactions undergo metathesis cascades to yield a collection of tricyclic sultams. Additional appendage-based diversity was achieved by utilizing a variety of CM partners. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2009.03.080