Smoking and the Risk of Psoriasis in Women: Nurses’ Health Study II

Abstract Background Psoriasis is a common, chronic, inflammatory skin disorder. Smoking may increase the risk of psoriasis, but no prospective data are available on this relation. Methods We prospectively examined over a 14-year time period (1991-2005) the relation between smoking status, duration,...

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Veröffentlicht in:The American journal of medicine 2007-11, Vol.120 (11), p.953-959
Hauptverfasser: Setty, Arathi R., MD, MPH, Curhan, Gary, MD, ScD, Choi, Hyon K., MD, DrPH
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Sprache:eng
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Zusammenfassung:Abstract Background Psoriasis is a common, chronic, inflammatory skin disorder. Smoking may increase the risk of psoriasis, but no prospective data are available on this relation. Methods We prospectively examined over a 14-year time period (1991-2005) the relation between smoking status, duration, intensity, cessation, and exposure to secondhand smoke, and incident psoriasis in 78,532 women from the Nurses Health Study II. The primary outcome was incident, self-reported, physician-diagnosed psoriasis. Results We documented 887 incident cases of psoriasis. Compared with those who had never smoked, the multivariate relative risk (RR) of psoriasis was 1.78 (95% confidence interval [CI], 1.46 to 2.16) for current smokers and 1.37 (95% CI, 1.17 to 1.59) for past smokers. Compared with nonsmokers, the multivariate RR of psoriasis was 1.60 (95% CI, 1.31 to 1.97) for those who had smoked 11-20 pack-years and 2.05 (95% CI, 1.66 to 2.53) for those who had smoked ≥21 pack-years. Compared with never smokers, the multivariate RR of psoriasis was 1.61 (95% CI, 1.30 to 2.00) for those who quit smoking
ISSN:0002-9343
1555-7162
DOI:10.1016/j.amjmed.2007.06.020