Functional properties of fibronectin in the trabecular meshwork

Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, we examine recent findings about...

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Veröffentlicht in:	Experimental eye research 2009-04, Vol.88 (4), p.689-693
Hauptverfasser:	Faralli, Jennifer A., Schwinn, Marie K., Gonzalez, Jose M., Filla, Mark S., Peters, Donna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous Humor - physiology fibronectin Fibronectins - chemistry Fibronectins - physiology HepII domain Humans integrins Receptors, Fibronectin - physiology Signal Transduction - physiology Structure-Activity Relationship trabecular meshwork Trabecular Meshwork - physiology
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Zusammenfassung:	Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, we examine recent findings about the biological and structural properties of fibronectin and discuss how these properties could contribute to the regulation of aqueous humor (AH) outflow in the trabecular meshwork (TM).
ISSN:	0014-4835 1096-0007
DOI:	10.1016/j.exer.2008.08.019