HIV-1 Antigens in Neurons of Cocaine-Abusing Patients

Cocaine opens the blood-brain barrier by deregulating transcription of target genes. Here we show that cocaine at blood concentrations in drug abusers disrupts endothelial cell junctions in parallel with signaling by phosphorylation of extracellular signal-regulated kinase, myristoylated alanine-ric...

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Veröffentlicht in:	The open virology journal 2008, Vol.2 (1), p.24-31
Hauptverfasser:	Fiala, Milan, Singer, Elyse J, Commins, Deborah, Mirzapoiazova, Tamara, Verin, Alexander, Espinosa, Araceli, Ugen, Kenneth, Bernas, Michael, Witte, Marlys, Weinand, Martin, Lossinsky, Albert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Human immunodeficiency virus 1
Online-Zugang:	Volltext
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Zusammenfassung:	Cocaine opens the blood-brain barrier by deregulating transcription of target genes. Here we show that cocaine at blood concentrations in drug abusers disrupts endothelial cell junctions in parallel with signaling by phosphorylation of extracellular signal-regulated kinase, myristoylated alanine-rich C kinase and myosin light chain. Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef.
ISSN:	1874-3579 1874-3579
DOI:	10.2174/1874357900802010024