Simultaneous estimation of attenuation and structure parameters of aggregated red blood cells from backscatter measurements
The analysis of the ultrasonic frequency-dependent backscatter coefficient of aggregating red blood cells reveals information about blood structural properties. The difficulty in applying this technique in vivo is due to the frequency-dependent attenuation caused by intervening tissue layers that di...
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Veröffentlicht in: | The Journal of the Acoustical Society of America 2008-04, Vol.123 (4), p.EL85-EL91 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
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Zusammenfassung: | The analysis of the ultrasonic frequency-dependent backscatter coefficient of aggregating red blood cells reveals information about blood structural properties. The difficulty in applying this technique
in vivo
is due to the frequency-dependent attenuation caused by intervening tissue layers that distorts the spectral content of backscattering properties from blood microstructures. An optimization method is proposed to simultaneously estimate tissue attenuation and blood structure factor. With
in vitro
experiments, the method gave satisfactory estimates with relative errors below 22% for attenuations between 0.101 and
0.317
dB
∕
cm
∕
MHz
, signal-to-noise
ratios
>
28
dB
and
k
R
<
2.7
(
k
being the wave number and
R
the aggregate radius). |
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ISSN: | 0001-4966 1520-8524 |
DOI: | 10.1121/1.2896115 |