Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection

Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical cord blood of 197 neonates were measured to evaluate their value as markers of infection. Sixteen of the neonates were infected. The sensitivity, specificity, and negative and positive predictive values were respectively 87...

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Veröffentlicht in:	Archives of disease in childhood. Fetal and neonatal edition 2006-01, Vol.91 (1), p.F65-F66
Hauptverfasser:	Joram, N, Boscher, C, Denizot, S, Loubersac, V, Winer, N, Roze, J C, Gras-Le Guen, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacterial infections Bacterial Infections - diagnosis Biomarkers - blood C reactive protein C-Reactive Protein - analysis Calcitonin - blood Calcitonin Gene-Related Peptide Confidence intervals cord blood CRP Early Diagnosis Epidemiologic Methods Fetal Blood - chemistry Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - diagnosis Infections Infectious Disease Transmission, Vertical maternofetal infection Neonates Newborn babies PCT Physiology procalcitonin Protein Precursors - blood Proteins Sepsis Sepsis - diagnosis Short Report Umbilical cord
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Zusammenfassung:	Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical cord blood of 197 neonates were measured to evaluate their value as markers of infection. Sixteen of the neonates were infected. The sensitivity, specificity, and negative and positive predictive values were respectively 87.5%, 98.7%, 87.5%, and 98.7% for PCT and 50%, 97%, 67%, and 94% for CRP. Serum PCT in cord blood seems to be a useful and early marker of antenatal infection.
ISSN:	1359-2998 1468-2052
DOI:	10.1136/adc.2005.074245