Common variants in WFS1 confer risk of type 2 diabetes

We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in...

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Veröffentlicht in:	Nature genetics 2007-08, Vol.39 (8), p.951-953
Hauptverfasser:	Sandhu, Manjinder S, Weedon, Michael N, Fawcett, Katherine A, Wasson, Jon, Debenham, Sally L, Daly, Allan, Lango, Hana, Frayling, Timothy M, Neumann, Rosalind J, Sherva, Richard, Blech, Ilana, Pharoah, Paul D, Palmer, Colin N A, Kimber, Charlotte, Tavendale, Roger, Morris, Andrew D, McCarthy, Mark I, Walker, Mark, Hitman, Graham, Glaser, Benjamin, Permutt, M Alan, Hattersley, Andrew T, Wareham, Nicholas J, Barroso, Inês
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Case-Control Studies Comparative studies Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Health risks Human Genetics Humans Insulin-Secreting Cells - cytology Insulin-Secreting Cells - physiology Medical sciences Membrane Proteins - genetics Mutation Pancreas Physiological aspects Polymorphism, Single Nucleotide Population genetics Risk factors Single nucleotide polymorphisms Type 2 diabetes
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Beschreibung
Zusammenfassung:	We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng2067