Glutamate receptor gene ( GRIN2B ) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive–compulsive disorder

Abstract In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between...

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Veröffentlicht in:	Psychiatry research. Neuroimaging 2009-05, Vol.172 (2), p.136-139
Hauptverfasser:	Arnold, Paul Daniel, MacMaster, Frank P, Richter, Margaret A, Hanna, Gregory L, Sicard, Tricia, Burroughs, Eliza, Mirza, Yousha, Easter, Phillip C, Rose, Michelle, Kennedy, James L, Rosenberg, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult and adolescent clinical studies Age Factors Anxiety disorders. Neuroses Biological and medical sciences Brain Child Female Genetic Variation Genotype Glutamate transporter Glutamic Acid - analysis Glutamic Acid - metabolism Gyrus Cinguli - metabolism Humans Magnetic Resonance Spectroscopy Male Medical sciences N-methyl- d-aspartate Obsessive-Compulsive Disorder - genetics Obsessive-Compulsive Disorder - metabolism Obsessive-compulsive disorders Occipital Lobe - metabolism Polymorphism, Genetic Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism
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Zusammenfassung:	Abstract In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N -methyl- d -aspartate 2B ( GRIN2B ) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
ISSN:	0925-4927 1872-7506
DOI:	10.1016/j.pscychresns.2009.02.005