Mixed Candida albicans strain populations in colonized and infected mucosal tissues

Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of typ...

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Veröffentlicht in:	FEMS yeast research 2008-12, Vol.8 (8), p.1334-1338
Hauptverfasser:	Jacobsen, Mette D, Duncan, Amanda D, Bain, Judith, Johnson, Elizabeth M, Naglik, Julian R, Shaw, Duncan J, Gow, Neil A.R, Odds, Frank C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Candida albicans Candida albicans - classification Candida albicans - genetics Candida albicans - isolation & purification Candidiasis, Oral - epidemiology Candidiasis, Oral - microbiology Candidiasis, Vulvovaginal - epidemiology Candidiasis, Vulvovaginal - microbiology Carrier State - microbiology Colonies Colonies & territories DNA, Fungal - analysis DNA, Fungal - genetics epidemiology Female Humans MLST Mucosa Mucous Membrane - microbiology Multilocus sequence typing Mycological Typing Techniques Oropharynx - microbiology Pathogenicity Sequence Analysis, DNA strain typing Vagina Vagina - microbiology Young Adult
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Zusammenfassung:	Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.
ISSN:	1567-1356 1567-1364
DOI:	10.1111/j.1567-1364.2008.00438.x