Pd(II)-Catalyzed Olefination of Electron-Deficient Arenes Using 2,6-Dialkylpyridine Ligands

Pd(II)-Catalyzed Olefination of Electron-Deficient Arenes Using 2,6-Dialkylpyridine Ligands

Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C−H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-...

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Veröffentlicht in:Journal of the American Chemical Society 2009-04, Vol.131 (14), p.5072-5074
Hauptverfasser: Zhang, Yang-Hui, Shi, Bing-Feng, Yu, Jin-Quan
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Catalysis
Electrons
Hydrocarbons, Aromatic - chemical synthesis
Hydrocarbons, Aromatic - chemistry
Ligands
Palladium - chemistry
Pyridines - chemistry
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Zusammenfassung:Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C−H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-trisubstituted arenes.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja900327e