Polymorphism in the IL18 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women

Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1 . To determine whether low-penetrance genetic variants contribute to ovarian cancer risk, we genotyped 1,536 single nucl...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-12, Vol.17 (12), p.3567-3572
Hauptverfasser:	Palmieri, Rachel T, Wilson, Melanie A, Iversen, Edwin S, Clyde, Merlise A, Calingaert, Brian, Moorman, Patricia G, Poole, Charles, Anderson, A Rebecca, Anderson, Stephanie, Anton-Culver, Hoda, Beesley, Jonathan, Hogdall, Estrid, Brewster, Wendy, Carney, Michael E, Chen, Xiaoqing, Chenevix-Trench, Georgia, Chang-Claude, Jenny, Cunningham, Julie M, Dicioccio, Richard A, Doherty, Jennifer A, Easton, Douglas F, Edlund, Christopher K, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Goode, Ellen L, Goodman, Marc T, Kjaer, Susanne Kruger, Hogdall, Claus K, Hopkins, Michael P, Jenison, Eric L, Blaakaer, Jan, Lurie, Galina, McGuire, Valerie, Menon, Usha, Moysich, Kirsten B, Ness, Roberta B, Pearce, Celeste Leigh, Pharoah, Paul D P, Pike, Malcolm C, Ramus, Susan J, Rossing, Mary Anne, Song, Honglin, Terada, Keith Y, Vandenberg, David, Vierkant, Robert A, Wang-Gohrke, Shan, Webb, Penelope M, Whittemore, Alice S, Wu, Anna H, Ziogas, Argyrios, Berchuck, Andrew, Schildkraut, Joellen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Chi-Square Distribution consortia Female Genetic Predisposition to Disease Genotype Humans IL18 inflammation Interleukin-18 - genetics Logistic Models Middle Aged Neoplasms, Glandular and Epithelial - genetics North Carolina ovarian cancer Ovarian Neoplasms - genetics Polymorphism, Single Nucleotide SNPs White People - genetics
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Zusammenfassung:	Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1 . To determine whether low-penetrance genetic variants contribute to ovarian cancer risk, we genotyped 1,536 single nucleotide polymorphisms (SNP) in several candidate gene pathways in 848 epithelial ovarian cancer cases and 798 controls in the North Carolina Ovarian Cancer Study (NCO) using a customized Illumina array. The inflammation gene interleukin-18 ( IL18 ) showed the strongest evidence for association with epithelial ovarian cancer in a gene-by-gene analysis ( P = 0.002) with a
ISSN:	1055-9965 1538-7755
DOI:	10.1158/1055-9965.EPI-08-0548