Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells

To investigate the anti-proliferative effects of Crocus sativus extract and its major constituent, crocin, on three colorectal cancer cell lines (HCT-116, SW-480, and HT-29). The cell growth inhibition effect was compared to that of non-small cell lung cancer (NSCLC) cells. In addition, Crocus sativ...

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Veröffentlicht in:Experimental oncology 2007-09, Vol.29 (3), p.175-180
Hauptverfasser: Aung, H H, Wang, C Z, Ni, M, Fishbein, A, Mehendale, S R, Xie, J T, Shoyama, C Y, Yuan, C S
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Sprache:eng
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Zusammenfassung:To investigate the anti-proliferative effects of Crocus sativus extract and its major constituent, crocin, on three colorectal cancer cell lines (HCT-116, SW-480, and HT-29). The cell growth inhibition effect was compared to that of non-small cell lung cancer (NSCLC) cells. In addition, Crocus sativus' effect on non-cancer cells was evaluated. Using high performance liquid chromatography (HPLC), the purity of crocin and the content of crocin extract were determined. Anti-proliferative effects of Crocus sativus extract and crocin on test cells was evaluated by MTS assay. The purity of crocin was found to be 95.9% and the content of crocin in the extract was 22.9%. Significant concentration-related inhibition effects of the extract on all three colorectal cancer cell lines were observed (P
ISSN:1812-9269