Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Renin-Angiotensin System Status in Hypertensive Patients

Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Renin-Angiotensin System Status in Hypertensive Patients

We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent hypertensive rats. To study this system in humans, we recently developed a human angiotensinogen ELISA. To test the hypothesi...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2009-02, Vol.53 (2, Part 2 Suppl), p.344-350
Hauptverfasser: Kobori, Hiroyuki, Alper, A Brent, Shenava, Rajesh, Katsurada, Akemi, Saito, Toshie, Ohashi, Naro, Urushihara, Maki, Miyata, Kayoko, Satou, Ryousuke, Hamm, L Lee, Navar, L Gabriel
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensinogen - urine
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Biomarkers - urine
Blood and lymphatic vessels
Blood Pressure - physiology
Cardiology. Vascular system
Case-Control Studies
Creatinine - urine
Endocrine kidney. Renin-angiotensin-aldosterone system
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Glomerular Filtration Rate - physiology
Humans
Hypertension - physiopathology
Hypertension - urine
Kidney - physiopathology
Male
Medical sciences
Middle Aged
Regression Analysis
Renin-Angiotensin System - physiology
Vertebrates: endocrinology
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Zusammenfassung:We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent hypertensive rats. To study this system in humans, we recently developed a human angiotensinogen ELISA. To test the hypothesis that UAGT is increased in hypertensive patients, we recruited 110 adults. Four subjects with estimated glomerular filtration levels
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.108.123802