Genome-wide association study of anthropometric traits in Korcula Island, Croatia
To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study. The study was carried out in the isolated population of the island of Korcula, Croa...
Gespeichert in:
Veröffentlicht in: | Croatian medical journal 2009-02, Vol.50 (1), p.7-16 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study.
The study was carried out in the isolated population of the island of Korcula, Croatia, with 898 adult examinees who participated in the larger DNA-based genetic epidemiological study in 2007. Anthropometric measurements followed standard internationally accepted procedures. Examinees were genotyped using HumanHap 370CNV chip by Illumina, with a genome-wide scan containing 316730 single nucleotide polymorphisms (SNP).
A total of 11 SNPs were associated with the investigated traits at the level of P |
---|---|
ISSN: | 0353-9504 1332-8166 |
DOI: | 10.3325/cmj.2009.50.7 |