Genome-wide association study of anthropometric traits in Korcula Island, Croatia

To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study. The study was carried out in the isolated population of the island of Korcula, Croa...

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Veröffentlicht in:Croatian medical journal 2009-02, Vol.50 (1), p.7-16
Hauptverfasser: Polasek, Ozren, Marusić, Ana, Rotim, Kresimir, Hayward, Caroline, Vitart, Veronique, Huffman, Jennifer, Campbell, Susan, Janković, Stipan, Boban, Mladen, Biloglav, Zrinka, Kolcić, Ivana, Krzelj, Vjekoslav, Terzić, Janos, Matec, Lana, Tometić, Gordan, Nonković, Dijana, Nincević, Jasna, Pehlić, Marina, Zedelj, Jurica, Velagić, Vedran, Juricić, Danica, Kirac, Iva, Belak Kovacević, Sanja, Wright, Alan F, Campbell, Harry, Rudan, Igor
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Sprache:eng
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Zusammenfassung:To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study. The study was carried out in the isolated population of the island of Korcula, Croatia, with 898 adult examinees who participated in the larger DNA-based genetic epidemiological study in 2007. Anthropometric measurements followed standard internationally accepted procedures. Examinees were genotyped using HumanHap 370CNV chip by Illumina, with a genome-wide scan containing 316730 single nucleotide polymorphisms (SNP). A total of 11 SNPs were associated with the investigated traits at the level of P
ISSN:0353-9504
1332-8166
DOI:10.3325/cmj.2009.50.7