Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model

Abstract Purpose This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model. Methods Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated. Results Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score. Conclusion Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.