Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis： A randomized placebo-controlled trial

AIM： To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography （ERCP） pancreatitis and hyperamylasemia. METHODS： Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers. RESULTS： A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients （7.9%） of the study group and 9 patients （25%） in the placebo group （P = 0.012）. Hyperamylasemia occurred in 8 patients of the study group （21.1%） and 13 patients （36.1%） of the placebo group （P = 0.037）. CONCLUSION： Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.