Peptide immobilized on gold particles enhances cell growth

Peptide immobilized on gold particles enhances cell growth

A multivalent ligand of thrombopoietin (TPO) was prepared by immobilization of mimetic peptides on gold particles. An effective peptide ligand containing cysteine was designed to enhance the growth of TPO-sensitive cells. The peptide was then immobilized on gold particles by self assembly. The multi...

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Veröffentlicht in:Cytotechnology (Dordrecht) 2008-11, Vol.58 (3), p.141-144
Hauptverfasser: Gong, Jiansheng, Ito, Yoshihiro
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biological activity
Biomedicine
Biotechnology
Cell culture
Chemistry
Chemistry and Materials Science
Electron microscopes
Immobilization
Ligands
Medical research
Peptides
Polyethylene glycol
Rheumatoid arthritis
Signal transduction
Thrombopoietin
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Zusammenfassung:A multivalent ligand of thrombopoietin (TPO) was prepared by immobilization of mimetic peptides on gold particles. An effective peptide ligand containing cysteine was designed to enhance the growth of TPO-sensitive cells. The peptide was then immobilized on gold particles by self assembly. The multivalent ligand enhanced the growth of TPO-dependent cells and its activity was more than that of the monovalent ligand.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-008-9179-3