Airway glutathione homeostasis is altered in children with severe asthma: Evidence for oxidant stress

Background Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species. Objectives Glutathione (GSH) is an important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH homeostasis was altered in children with seve...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2009, Vol.123 (1), p.146-152.e8
Hauptverfasser:	Fitzpatrick, Anne M., PhD, Teague, W. Gerald, MD, Holguin, Fernando, MD, Yeh, Mary, PhD, Brown, Lou Ann S., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	8-isoprostanes Adolescent Adult Airway management Allergy and Immunology Antioxidants - metabolism Asthma Asthma - metabolism Biological and medical sciences Biomarkers - metabolism Bronchoalveolar Lavage Fluid Child Child, Preschool children Cough - metabolism Dinoprost - analogs & derivatives Dinoprost - metabolism Female Fundamental and applied biological sciences. Psychology Fundamental immunology glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - genetics Glutathione Transferase - metabolism Homeostasis Humans hydrogen peroxide Hydrogen Peroxide - metabolism Lung - metabolism Male malondialdehyde Malondialdehyde - metabolism Medical sciences Oxidation-Reduction Oxidative Stress Pediatrics Premature birth redox potential Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Variables Voice Disorders - metabolism
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Zusammenfassung:	Background Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species. Objectives Glutathione (GSH) is an important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH homeostasis was altered in children with severe asthma and was characterized by decreased GSH and increased glutathione disulfide (GSSG) concentrations. Methods Bronchoalveolar lavage was obtained from 65 children with severe asthma, including 35 children with baseline airway obstruction evidenced by FEV1
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2008.10.047