Congenital anomalies in multiple births after early loss of a conceptus
Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data w...
Gespeichert in:
| Veröffentlicht in: | Human reproduction (Oxford) 2009-03, Vol.24 (3), p.726-731 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 731 |
|---|---|
| container_issue | 3 |
| container_start_page | 726 |
| container_title | Human reproduction (Oxford) |
| container_volume | 24 |
| creator | Pharoah, P.O.D. Glinianaia, S.V. Rankin, J. |
| description | Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data were abstracted from the UK population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey, 1998–2004. Results Among 3311 twin conceptions, both conceptuses were lost at |
| doi_str_mv | 10.1093/humrep/den436 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2646789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/den436</oup_id><sourcerecordid>20896333</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-b19f3c81df84281022f5fc7006506602aa790d1673b59350f0a4483c826773953</originalsourceid><addsrcrecordid>eNqFkc2PFCEQxYnRuOPo0ashJhov7QINdHMx0YnOmmxiNBrNXgjDwA4rDS3Qxv3vZdOd8eOyXCCpH6-q3gPgMUYvMRLt6WEakhlP9ybQlt8BK0w5akjL0F2wQoT3DcYcn4AHOV8hVJ89vw9OsEBMCMpWYLuJ4dIEV5SHKsRBeWcydAEOky9u9AbuXCqHDJUtJkGjkr-GPuYMo4UK6hi0GcuUH4J7VvlsHi33Gnx59_bz5qw5_7B9v3l93mhGaWl2WNhW93hve0p6jAixzOoOIc4Q54go1Qm0x7xrd0zUJSxSlPb1B-Fd1wrWrsGrWXecdoPZaxNKUl6OyQ0qXcuonPy3EtxBXsafknDKu15UgeeLQIo_JpOLHFzWxnsVTJyy5FywXrDuVpCgXvC2njV4-h94FacUqguSYCwY6fCNWjNDOlXzkrHHkTGSN0HKOUg5B1n5J3_v-YdekqvAswVQWStvkwra5SNXO1ffKK7ci5mL03hrz2VGl4v5dYRV-i5rIB2TZ98uJPn05uIrYh_ltv0NmV3ERw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211952717</pqid></control><display><type>article</type><title>Congenital anomalies in multiple births after early loss of a conceptus</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Pharoah, P.O.D. ; Glinianaia, S.V. ; Rankin, J.</creator><creatorcontrib>Pharoah, P.O.D. ; Glinianaia, S.V. ; Rankin, J.</creatorcontrib><description>Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data were abstracted from the UK population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey, 1998–2004. Results Among 3311 twin conceptions, both conceptuses were lost at <16 weeks gestation in 67, and one conceptus in 142 conceptions. Of the 142 singleton survivors, two died in infancy, two were terminated for a congenital anomaly and 11 of 138 had a congenital anomaly (prevalence 915.5 per 10 000 births). There were 197 congenital anomalies among 5948 registered twin births (331.2 per 10 000). The relative risk (RR) of congenital anomalies in a singleton with early loss of a conceptus and twins was 2.40 [95% confidence interval (CI): 1.34–4.29]. There were 4265 infants with a congenital anomaly among the 206 914 singletons [206.1 per 10 000 births: RR twin:singleton 1.61 (95% CI 1.40–1.89)]. Conclusions A highly significant increase in the risk of congenital anomaly in survivors from a multiple conception following early loss of a conceptus supports the hypothesis that many congenital anomalies are associated with monozygotic multiple conceptions.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/den436</identifier><identifier>PMID: 19059945</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abortion, Spontaneous ; Biological and medical sciences ; Congenital Abnormalities - diagnosis ; Congenital Abnormalities - epidemiology ; congenital anomalies ; Diseases in Twins - etiology ; early fetal loss ; England ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Medical sciences ; Multiple Birth Offspring ; multiple pregnancies ; Original ; Pregnancy ; Pregnancy, Multiple ; Registries ; Risk ; Risk Factors ; twins ; Twins, Monozygotic</subject><ispartof>Human reproduction (Oxford), 2009-03, Vol.24 (3), p.726-731</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2009</rights><rights>2009 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-b19f3c81df84281022f5fc7006506602aa790d1673b59350f0a4483c826773953</citedby><cites>FETCH-LOGICAL-c544t-b19f3c81df84281022f5fc7006506602aa790d1673b59350f0a4483c826773953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21148341$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19059945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pharoah, P.O.D.</creatorcontrib><creatorcontrib>Glinianaia, S.V.</creatorcontrib><creatorcontrib>Rankin, J.</creatorcontrib><title>Congenital anomalies in multiple births after early loss of a conceptus</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data were abstracted from the UK population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey, 1998–2004. Results Among 3311 twin conceptions, both conceptuses were lost at <16 weeks gestation in 67, and one conceptus in 142 conceptions. Of the 142 singleton survivors, two died in infancy, two were terminated for a congenital anomaly and 11 of 138 had a congenital anomaly (prevalence 915.5 per 10 000 births). There were 197 congenital anomalies among 5948 registered twin births (331.2 per 10 000). The relative risk (RR) of congenital anomalies in a singleton with early loss of a conceptus and twins was 2.40 [95% confidence interval (CI): 1.34–4.29]. There were 4265 infants with a congenital anomaly among the 206 914 singletons [206.1 per 10 000 births: RR twin:singleton 1.61 (95% CI 1.40–1.89)]. Conclusions A highly significant increase in the risk of congenital anomaly in survivors from a multiple conception following early loss of a conceptus supports the hypothesis that many congenital anomalies are associated with monozygotic multiple conceptions.</description><subject>Abortion, Spontaneous</subject><subject>Biological and medical sciences</subject><subject>Congenital Abnormalities - diagnosis</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>congenital anomalies</subject><subject>Diseases in Twins - etiology</subject><subject>early fetal loss</subject><subject>England</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Birth Offspring</subject><subject>multiple pregnancies</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pregnancy, Multiple</subject><subject>Registries</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>twins</subject><subject>Twins, Monozygotic</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2PFCEQxYnRuOPo0ashJhov7QINdHMx0YnOmmxiNBrNXgjDwA4rDS3Qxv3vZdOd8eOyXCCpH6-q3gPgMUYvMRLt6WEakhlP9ybQlt8BK0w5akjL0F2wQoT3DcYcn4AHOV8hVJ89vw9OsEBMCMpWYLuJ4dIEV5SHKsRBeWcydAEOky9u9AbuXCqHDJUtJkGjkr-GPuYMo4UK6hi0GcuUH4J7VvlsHi33Gnx59_bz5qw5_7B9v3l93mhGaWl2WNhW93hve0p6jAixzOoOIc4Q54go1Qm0x7xrd0zUJSxSlPb1B-Fd1wrWrsGrWXecdoPZaxNKUl6OyQ0qXcuonPy3EtxBXsafknDKu15UgeeLQIo_JpOLHFzWxnsVTJyy5FywXrDuVpCgXvC2njV4-h94FacUqguSYCwY6fCNWjNDOlXzkrHHkTGSN0HKOUg5B1n5J3_v-YdekqvAswVQWStvkwra5SNXO1ffKK7ci5mL03hrz2VGl4v5dYRV-i5rIB2TZ98uJPn05uIrYh_ltv0NmV3ERw</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Pharoah, P.O.D.</creator><creator>Glinianaia, S.V.</creator><creator>Rankin, J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Congenital anomalies in multiple births after early loss of a conceptus</title><author>Pharoah, P.O.D. ; Glinianaia, S.V. ; Rankin, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-b19f3c81df84281022f5fc7006506602aa790d1673b59350f0a4483c826773953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abortion, Spontaneous</topic><topic>Biological and medical sciences</topic><topic>Congenital Abnormalities - diagnosis</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>congenital anomalies</topic><topic>Diseases in Twins - etiology</topic><topic>early fetal loss</topic><topic>England</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Birth Offspring</topic><topic>multiple pregnancies</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pregnancy, Multiple</topic><topic>Registries</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>twins</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pharoah, P.O.D.</creatorcontrib><creatorcontrib>Glinianaia, S.V.</creatorcontrib><creatorcontrib>Rankin, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pharoah, P.O.D.</au><au>Glinianaia, S.V.</au><au>Rankin, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital anomalies in multiple births after early loss of a conceptus</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>24</volume><issue>3</issue><spage>726</spage><epage>731</epage><pages>726-731</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data were abstracted from the UK population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey, 1998–2004. Results Among 3311 twin conceptions, both conceptuses were lost at <16 weeks gestation in 67, and one conceptus in 142 conceptions. Of the 142 singleton survivors, two died in infancy, two were terminated for a congenital anomaly and 11 of 138 had a congenital anomaly (prevalence 915.5 per 10 000 births). There were 197 congenital anomalies among 5948 registered twin births (331.2 per 10 000). The relative risk (RR) of congenital anomalies in a singleton with early loss of a conceptus and twins was 2.40 [95% confidence interval (CI): 1.34–4.29]. There were 4265 infants with a congenital anomaly among the 206 914 singletons [206.1 per 10 000 births: RR twin:singleton 1.61 (95% CI 1.40–1.89)]. Conclusions A highly significant increase in the risk of congenital anomaly in survivors from a multiple conception following early loss of a conceptus supports the hypothesis that many congenital anomalies are associated with monozygotic multiple conceptions.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19059945</pmid><doi>10.1093/humrep/den436</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-1161 |
| ispartof | Human reproduction (Oxford), 2009-03, Vol.24 (3), p.726-731 |
| issn | 0268-1161 1460-2350 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2646789 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Abortion, Spontaneous Biological and medical sciences Congenital Abnormalities - diagnosis Congenital Abnormalities - epidemiology congenital anomalies Diseases in Twins - etiology early fetal loss England Female Gestational Age Gynecology. Andrology. Obstetrics Humans Male Medical sciences Multiple Birth Offspring multiple pregnancies Original Pregnancy Pregnancy, Multiple Registries Risk Risk Factors twins Twins, Monozygotic |
| title | Congenital anomalies in multiple births after early loss of a conceptus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T13%3A35%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Congenital%20anomalies%20in%20multiple%20births%20after%20early%20loss%20of%20a%20conceptus&rft.jtitle=Human%20reproduction%20(Oxford)&rft.au=Pharoah,%20P.O.D.&rft.date=2009-03-01&rft.volume=24&rft.issue=3&rft.spage=726&rft.epage=731&rft.pages=726-731&rft.issn=0268-1161&rft.eissn=1460-2350&rft.coden=HUREEE&rft_id=info:doi/10.1093/humrep/den436&rft_dat=%3Cproquest_pubme%3E20896333%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211952717&rft_id=info:pmid/19059945&rft_oup_id=10.1093/humrep/den436&rfr_iscdi=true |