Congenital anomalies in multiple births after early loss of a conceptus

Congenital anomalies in multiple births after early loss of a conceptus

Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data w...

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Veröffentlicht in:Human reproduction (Oxford) 2009-03, Vol.24 (3), p.726-731
Hauptverfasser: Pharoah, P.O.D., Glinianaia, S.V., Rankin, J.
Format: Artikel
Sprache:eng
Schlagworte:
Abortion, Spontaneous
Biological and medical sciences
Congenital Abnormalities - diagnosis
Congenital Abnormalities - epidemiology
congenital anomalies
Diseases in Twins - etiology
early fetal loss
England
Female
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Multiple Birth Offspring
multiple pregnancies
Original
Pregnancy
Pregnancy, Multiple
Registries
Risk
Risk Factors
twins
Twins, Monozygotic
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Zusammenfassung:Background Congenital anomalies are more common in twins than singletons but in the majority, aetiology is not known. Our aim was to test the hypothesis that survivors of an early loss in a multiple conception, compared with all singletons, are at increased risk of congenital anomaly. Methods Data were abstracted from the UK population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey, 1998–2004. Results Among 3311 twin conceptions, both conceptuses were lost at
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/den436